ترجمه مقاله با عنوان Nano graphene oxide: A novel carrier for oral delivery of flavonoids

اختصاصی از فی گوو ترجمه مقاله با عنوان Nano graphene oxide: A novel carrier for oral delivery of flavonoids دانلود با لینک مستقیم و پر سرعت .

متن کامل ترجمه مقاله ISI در elsevier در فایل word به فروش می رسد که ترجمه چکیده آن را به عنوان نمونه می توانید ملاحظه فرمایید.

تعداد کلمات مقاله: 4678

Nano  graphene oxide: A novel carrier for oral delivery of flavonoids

Abstract

The interesting physical and chemical properties of graphene oxide (GO) have led to much excitement among biomedical scientists in recent years. It is known that many potent, often aromatic medicines are water insoluble, and this has hindered their administration to treat diseases. Nano GO was synthesized and investigated for its biological application as a carrier for quercetin, a focused bioactive flavonoid widely used as a health supplement and a drug candidate. Different techniques were used to fully evaluate the synthesis, cytotoxicity, and quercetin loading capacity of nano GO. AFM and TEM results confirmed the preparation of planar nanoparticles without aggregation which was verified by reported size results (30 nm) obtained with a particle size analyzer. FTIR and DSC results proved the drug–carrier interaction. In vitro cytotoxicity assays showed that nano GO had no cytotoxicity on A549 cells in different amounts after incubation for 72 h, confirming its suitability as a drug carrier. Our results showed that nano GO can be proposed as a new carrier due to its small size, large specific surface area, low cost, and useful non-covalent interactions with aromatic low-soluble flavonoids such as quercetin. Moreover, it may find widespread applications in biomedicine.

نانو اکسید گرافن: یک حامل جدید برای تحویل خوراکی فلاونوئید ها

چکیده:

در سال های اخیر، خواص فیزیکی و شیمیایی جالب اکسید گرافن (GO)، منجر به هیجان زیادی در میان دانشمندان زیست پزشکی شده است. مشخص شده است که اغلب داروهای آروماتیک نامحلول در آب هستند، و این مانع برای درمان بیماری است. به دلیل کاربرد زیستی نانو GO به عنوان یک حامل برای کورستین (یک فلاونوئید فعال زیستی متمرکز که به طور گسترده به عنوان یک مکمل سلامت و گزینه دارویی استفاده می­شود)، سنتز و بررسی شده است. تکنیک های مختلفی برای بررسی کامل سنتز، سمیت سلولی، و ظرفیت بارگیری کورستین از نانو GO استفاده شد. نتایج AFM و TEM تهیه نانوذرات مسطح بدون تجمع را تایید می­کنند که با نتایج اندازه (30 نانومتر) به دست آمده با تجزیه و تحلیل اندازه ذرات سازگار است. نتایج FTIR و DSC برهمکنش دارو-حامل را ثابت کرد. سنجش سمیت سلولی آزمایشگاهی نشان داد که نانو GO هیچ سمیت سلولی بر سلول های A549 در مقادیر مختلف پس از انکوباسیون به مدت 72 ساعت ندارد، که مناسب بودن آن را به عنوان حامل دارو تایید می­کند. نتایج ما نشان داد که نانو GO به دلیل اندازه کوچک، مساحت سطحی ویژه بالا، هزینه پایین، و برهمکنش های غیر کووالانسی با فلاونوئیدهای کم محلول آروماتیک مانند کورستین می­تواند به عنوان یک حامل جدید ارائه شود. علاوه بر این، ممکن است کاربردهای گسترده ای در تحقیقات زیست پزشکی پیدا کند.

براش های مرتبط با ساخت کمیک و مانگا Brush For Creating Manga and Comic

اختصاصی از فی گوو براش های مرتبط با ساخت کمیک و مانگا Brush For Creating Manga and Comic دانلود با لینک مستقیم و پر سرعت .

براش های مرتبط با ساخت کمیک و مانگا Brush For Creating Manga and Comic

براش های آماده مو، چشم، علایم، پُشت زمینه و ... که به شما بسیار در ساخت کارهای گرافیکیتان کمک خواهند کرد

نمونه

COMPUTER MODELING OF A WASTE OF TRANSMUTATION ADM FOR HYDROGEN PRODUCTION

اختصاصی از فی گوو COMPUTER MODELING OF A WASTE OF TRANSMUTATION ADM FOR HYDROGEN PRODUCTION دانلود با لینک مستقیم و پر سرعت .

Title : MODELAGEM COMPUTACIONAL DE UM ADS PARA TRANSMUTAÇÃO DE REJEITOS E PRODUÇÃO DE HIDROGENIO

language :  Portuguese

Abstract

Nuclear fission devices coupled to particle accelerators ADS (Accelerator Driven System-ADS) are being widely studied. These devices have many applications, including nuclear waste transmutation and production of hydrogen, both with significant social and environmental impact. The main objective of this dissertation was to use probabilistic methods of computational modeling to simulate ADS geometry with TRISO fuel. Specifically, we were concern with the characterization of the spallation region of ADS geometry for three different target materials: lead, uranium and tungsten. New studies on the deep burns strategy of the TRISO fuel in the pebble bed ADS were also carried out as a part
of this project. Several aspects were evaluated for characterizing the spallation target, including the neutron source intensity, neutrons, photons, and electrons spectra and the neutron production per energy unit of incident proton as function of beam energy, target material and geometric dimensions. In addition, the variations of the neutron flux, the thermal power, the effective multiplication factor (keff), and the isotopic composition of the TRISO fuel, during the stationary cycle for minor actinides and plutonium isotopes, were studied as a function of the simulated target materials. The recharge cycles during one year of reactor operation for each simulated target were determined by the decreasing of thermal power to a set minimum value. Modeling was performed using Monte Carlo code MCNPX 2.6E. It can be concluded, from the optimization study of the solid target dimension in cylindrical geometry, that the neutron production per incident proton for the three considered target
materials increases with the increasing of the spallation target dimensions of (thickness and radius) until it achieves the highest production of neutrons per incident proton or the saturation region. The solid target of tungsten material is the target that offers better features. From the analysis of the ADS geometry modeling with TRISO fuel we concluded that the extension of burning time without recharging in the reactor core is the key factor to reduce the masses of the plutonium isotopes and minor actinides in the core. It is then necessary to modify the geometrical configuration proposed for the subcritical core, in order to increase the power and neutron flux in the core. The power increment in the core is the main future goal of this dissertation.

A Fortran Program for Elastic Scattering Analyses with the Nuclear Optical Model

اختصاصی از فی گوو A Fortran Program for Elastic Scattering Analyses with the Nuclear Optical Model دانلود با لینک مستقیم و پر سرعت .

The purpose of the present report is to describe in complete detail a FORTRAN code
named Program SCAT 4 written by the UCLA group in order to analyze elastic scattering
of various particles against complex nuclei by means of the diffuse surface optical model
of the nucleus.
While a number of similar programs have been prepared and used by other groups,
there have been many requests for the UCLA program because of its flexibility and the
availability of IBM 704 and 709 computers for which the program is written.
The present program still contains some undesirable features and the UCLA group is
constantly modifying it to make it more efficient and flexible. However, a “final” program
will probably never be reached and it was decided to release Program SCAT 4 without
further delay; as they develop, modifications and additions will be described in later
reports.

DIDO - Life For Rent

اختصاصی از فی گوو DIDO - Life For Rent دانلود با لینک مستقیم و پر سرعت .

آهنگ بیاد ماندنی دیدو به نام زندگی برای اجاره که در سال 2003 منتشر گردید یکی از پرفروش ترین آلبوه های آن سال ها بود